The Saitama-based squad asserted its mastery of the home team to complete a sweep of their matches in the opening weekend of the Division 1 league.
Ageo Medics fought back from a 20-22 deficit in the third set as Mami Uchiseto delivered three straight clutch attacks to take a 23-22 lead followed by an ace from Yuka Sato and the game-winning attack of Kyoko Aoyagi.
Tamari Yamaguchi powered Saitama with 14 points. Aoyagi delivered 12 markers, while Uchiseto had 11.
Sato, who erupted for 40 points on Saturday’s five-set win, also finished with 11 points.
Santiago scored 10 points from six kills, two blocks and as many as aces as Ageo Medics took the early 2-0 lead.
Okayama dropped to 0-2 card with Aimi Sato being the lone bright spot with nine points.
Syuka Kaneda, who recorded 28 points in the first game, was held to just four attacks out of 21 attempts.
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