Murray had 20 points on 8 for 13 shooting, while White also had 20 points, going 8 for 14 as the Spurs notched their third win in five games in the preseason.
The Spurs took control with a 30-21 first period and never looked back.
Christian Wood scored 19 for the Rockets, 1-3 in the preseason.
Jalen Green had 16 points on 4 of 12 shooting, including 1 for 6 from beyond the arc.
Kevin Porter Jr. also scored 16 for the Rockets, making 6 of 20 shots.
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