Deandre Ayton had 14 points and 11 rebounds as the Suns outscored the Lakers 27-21 in the opening period and never looked back.
Mikal Bridges came up with 15 points, while Cameron Johnson came off the bench to score 13.
Chris Paul had eight points and 11 assists for Phoenix, which was without Devin Booker.
Malik Monk came off the bench to lead the Lakers with 18 points.
Anthony Davis had 14 points, eight rebounds and two assists in 25 minutes of action.
Carmelo Anthony played 17 minutes, delivering eight points, two rebounds, an assist and a steal.
Deandre Ayton and the Suns overcome Anthony Davis and the Lakers
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